ISN Audio Neo 3 vs Etymotic ER4XR

Last updated: October 17, 2026

Short answer: the ISN Audio Neo 3. It ranks #1054 of 1369 in-ear headphones by sound quality, rated 3.1/5, at $99; the Etymotic ER4XR ranks #1060, rated 3.0/5, and costs $299, so there is little reason to consider the other one.

ISN Audio Neo 3 vs Etymotic ER4XR

What the ISN Audio Neo 3 does well: A published AutoEQ preset corrects its response toward the Harman target, so a few minutes of EQ setup closes most of the gap. The catch: Treble about 2 dB below target from 3 to 10 kHz, which can sound dull or veiled next to brighter headphones.

Why pick the Etymotic ER4XR: Upper mids sit within 0.5 dB of the Harman target and low mids within 0.4 dB, so vocals and instruments come through clearly and naturally. The catch: Sub-bass is about 7.2 dB under target and bass is 2.6 dB low, so kick drums and bass lines lack weight and rumble.

Buy the ISN Audio Neo 3. It is rated higher for sound quality than the Etymotic ER4XR and costs less, so it is the default pick unless a specific strength of the other one matters more to you.

Looking for alternatives? See the complete Headphones rankings.

ISN Audio Neo 3

A published AutoEQ preset corrects its response toward the Harman target, so a few minutes of EQ setup closes most of the gap.

Penon Audio eBay
99
Etymotic ER4XR

Upper mids sit within 0.5 dB of the Harman target and low mids within 0.4 dB, so vocals and instruments come through clearly and naturally.

Amazon $299.00 eBay
$299

Prices on this page were last checked October 17, 2026 at 6:04 PM UTC. Product prices and availability are accurate as of that date/time and are subject to change; the price and availability shown on Amazon at the time of purchase will apply to the purchase of this product.

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Specifications Side By Side

ISN Audio Neo 3 Etymotic ER4XR
Price99.00$299.00
Ranked#1054 of 1369 in In-Ear Headphones#1060 of 1369 in In-Ear Headphones
Form FactorIn-earIn-ear
BackClosedClosed
Harman Preference Score63 (median of 6 squig.link measurements, calibrated to AutoEQ)62 (measured by oratory1990, via AutoEQ)
Deviation From Target2.70 dB standard deviation3.06 dB standard deviation
Tonal Tilt-0.70 (negative is warmer, positive brighter)+0.61 (negative is warmer, positive brighter)
Sub-bass ExtensionWithin 6 dB of target down to 20 Hz (-0.9 dB at 30 Hz)Falls 6 dB below target at 47 Hz (-7.0 dB at 30 Hz)
ConnectionWiredWired
Driver TypeHybrid (2 Dynamic + 1 Planar)Balanced armature
Drivers2 x 6mm dynamic drivers (1 low, 1 mid) + 1 x 5.8mm micro-planar driver (high)1 x balanced armature
Impedance15 ohms45 ohms
Sensitivity105 dB-
Frequency Response10Hz - 20kHz20Hz - 16kHz (Manufacturer specified)

Frequency Response Compared

Both headphones’ measurements overlaid on the Harman target. Above the target sounds louder in that range, below it quieter. Each curve is the median of several independent measurements, shifted so its 500 Hz to 2 kHz average sits at 0 dB, so only the tuning is compared.

ISN Audio Neo 3Etymotic ER4XRHarman target
Frequency response of the ISN Audio Neo 3 and Etymotic ER4XR-24-18-12-60+6+12+18dB20501002005001k2k5k10k20k

Measurement data: the ISN Audio Neo 3 from avishai, flare, pw, soundcheck39, theaudiostore and treblewellxtended; the Etymotic ER4XR from aden, dchpgall, dentreviews, musicafe, precog and superreview, all via squig.link.

How ISN Audio Neo 3 compares with other leading options: